This laboratory aims to develop new methods of examination and uncover the pathology of diseases such as arterial sclerosis and Alzheimer’s disease.
Recent research has shown that lipid hydroperoxides play a large role in many diseases and conditions including arterial sclerosis, obesity and aging. Due to its unstable nature, lipid hydroperoxides (LOOH) cannot be obtained as a commercialized product, and until now it was impossible to take LOOH measurements at the atomic level without synthetic chemistry techniques. Our research seeks to establish the chemical synthetic procedures for various species of lipid peroxides (cholesteryl esters, triacylglycerides, phospholipids etc.) and to measure species-specific lipid peroxide levels using chemiluminescence HPLC and LC/MS.
In Alzheimer’s disease, a reduction in the blood concentration of plasmalogen has been reported. Plasmalogen is a lipid which is highly abundant in the brain. This laboratory also uses its own unique techniques to analyze and synthesize plasmalogen.
By contrast, there are an increasing number of ectopic fat storage diseases, in which lipid droplets evoke damage in various organs. This lab predicted that the chain reaction of lipid droplet peroxidation and mitochondrial destruction can ultimately lead to cell death. Our aim is to identify dietary constituents which inhibit this reaction and prevent the development of ectopic fat storage diseases. We have developed a system for the selection and extraction of lipid droplets from cells, and their subsequent assessment using lipid peroxide analysis methods.
Furthermore, we also experimentally assess various antioxidants using this system. Through high functionality food materials, we will contribute to the realization of a “happy society, supported by healthy life”.